Pap Test May Prove Useful at Detecting More Types of Cancer, Study Suggests

The Pap test, which has prevented countless deaths from cervical cancer, may eventually help to detect cancers of the uterus and ovaries as well, a new study suggests.

For the first time, researchers have found genetic material from uterine or ovarian cancers in Pap smears, meaning that it may become possible to detect three diseases with just one routine test.

But the research is early, years away from being used in medical practice, and there are caveats. The women studied were already known to have cancer, and while the Pap test found 100 percent of the uterine cancers, it detected only 41 percent of the ovarian cancers. And the approach has not yet been tried in women who appear healthy, to determine whether it can find early signs of uterine or ovarian cancer.

On the other hand, even a 41 percent detection rate would be better than the status quo in ovarian cancer, particularly if the detection extends to early stages. The disease is usually advanced by the time it is found, and survival is poor. About 22,280 new cases were expected in the United States in 2012, and 15,500 deaths. Improved tests are urgently needed.

Uterine cancer has a better prognosis, but still kills around 8,000 women a year in the United States.

These innovative applications of the Pap test are part of a new era in which advances in genetics are being applied to the detection of a wide variety of cancers or precancerous conditions. Scientists are learning to find minute bits of mutant DNA in tissue samples or bodily fluids that may signal the presence of hidden or incipient cancers. Ideally, the new techniques would find the abnormalities early enough to cure the disease or even prevent it entirely. But it is too soon to tell.

“Is this the harbinger of things to come? I would answer yes,” said Dr. Bert Vogelstein, director of the Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins University, and a senior author of a report on the Pap test study published on Wednesday in the journal Science Translational Medicine. He said the genomes of more than 50 types of tumors had been sequenced, and researchers were trying to take advantage of the information.

Similar studies are under way or are being considered to look for mutant DNA in blood, stool, urine and sputum, both to detect cancer and also to monitor the response to treatment in people who already have the disease.

But researchers warn that such tests, used for screening, can be a double-edged sword if they give false positive results that send patients down a rabbit hole of invasive tests and needless treatments. Even a test that finds only real cancers may be unable to tell aggressive, dangerous ones apart from indolent ones that might never do any harm, leaving patients to decide whether to watch and wait or to go through surgery, chemotherapy and radiation with all the associated risks and side effects.

“Will they start recovering mutations that are not cancer-related?” asked Dr. Christopher P. Crum, a professor at Harvard Medical School who was not involved in the research.

But he also called the study a “great proof of principle,” and said, “Any whisper of hope to women who suffer from endometrial or ovarian cancer would be most welcome.”

DNA testing is already performed on samples from Pap tests, to look for the human papillomavirus, or HPV, which causes cervical cancer. Dr. Vogelstein and his team decided to try DNA testing for cancer. They theorized that cells or DNA shed from cancers of the ovaries and the uterine lining, or endometrium, might reach the cervix and turn up in Pap smears.

The team picked common mutations found in these cancers, and looked for them in tumor samples from 24 women with endometrial cancer and 22 with ovarian cancer. All the cancers had one or more of the common mutations.

Then, the researchers performed Pap tests on the same women, and looked for the same DNA mutations in the Pap specimens. They found the mutations in 100 percent of the women with endometrial cancer, but in only 9 of the 22 with ovarian cancer. The test identified two of the four ovarian cancers that had been diagnosed at an early stage.

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Obama’s Pick for Treasury Is Said to Be His Chief of Staff

WASHINGTON – President Obama will announce on Thursday that he intends to elevate his chief of staff and former budget director, Jacob J. Lew, to be his next secretary of Treasury, according to officials familiar with the decision.

If confirmed by the Senate, Mr. Lew, 57, would be Mr. Obama’s second Treasury secretary, replacing Timothy F. Geithner, the last remaining principal on Mr. Obama’s original economic team, at the head of that team.

While Mr. Lew has much less experience than Mr. Geithner in international economics and financial markets, he would come to the job with far more expertise in fiscal policy and in dealing with Congress than Mr. Geithner did when he became secretary at the start of Mr. Obama’s term. That shift in skills reflects the changed demands of the times, as emphasis has shifted from the global recession and financial crisis of the president’s first years to the continuing budget fights with Republicans in Congress to stabilize the growth of federal debt.

The partisan tension over the budget between Mr. Obama and Republicans suggests that Mr. Lew will face a grilling by Senate Republicans in confirmation hearings. But despite weeks of speculation that Mr. Lew would be named Treasury secretary, Republicans have not signaled that they plan to mount the kind of opposition they raised to Mr. Obama’s potential nomination of Susan E. Rice, the ambassador to the United Nations, for secretary of state, and Chuck Hagel as secretary of defense; the president named Mr. Hagel on Monday, and eventually settled on Senator John F. Kerry, Democrat of Massachusetts, for secretary of state.

Mr. Lew’s departure would create an important vacancy for what would be Mr. Obama’s fifth White House chief of staff, a turnover rate that is in contrast with the stability at Mr. Geithner’s Treasury. Leading candidates are said to include Denis McDonough, currently the deputy national security adviser in the White House; and Ron Klain, a former chief of staff to Vice President Joseph R. Biden Jr.

Mr. Lew had a brief turn in the financial industry before joining the Obama administration four years ago, working at the financial giant Citicorp, first as managing director of Citi Global Wealth Management and then as chief operating officer of Citigroup Alternative Investments.

His first job with Mr. Obama was at the State Department, where Mr. Lew was the deputy secretary responsible for managing day-to-day operations of the department and its international economic policy. Secretary of State Hillary Rodham Clinton protested to Mr. Obama when the president in 2010 tapped Mr. Lew to replace Peter R. Orszag as budget director.

It was Mr. Lew’s second stint heading the Office of Management and Budget. He previously served in President Bill Clinton’s second term, helping to negotiate a bipartisan budget deal with Congressional Republicans that led to four years of budget surpluses. In the 1980s, Mr. Lew was a senior aide to House Speaker Thomas P. O’Neill, a Democrat, also advising in budget negotiations with President Ronald Reagan.

He has been deeply involved in the deficit negotiations over the last two years. And, if he were quickly confirmed, as Treasury secretary his first test could come as soon as next month, when analysts expect a fight over raising the debt ceiling, which is the legal limit on the amount that the government can borrow.

Republican leaders have said they would refuse to raise the ceiling unless Mr. Obama agrees to equal spending cuts, particularly in entitlement programs like Medicare and Social Security. Mr. Obama has said that he will not negotiate over the ceiling, with the country’s full faith and credit at stake.

With battle lines already drawn, the country is expected to run out of room under the ceiling sometime between mid-February and March. At that point, Congress would need to raise the borrowing limit, or the country would start defaulting on obligated payments, like those promised to seniors, doctors, contractors and bondholders.

Mr. Lew’s role as an Obama negotiator in 2011 did not endear him to Republicans, in particular House Speaker John A. Boehner, and he took a lower-profile role in the most recent negotiations at year-end. The White House was eager to avoid controversy given the likelihood of Mr. Lew’s nomination to Treasury. Instead Mr. Geithner and Rob Nabors, the director of legislative affairs, were lead negotiators.

Mr. Lew, a native of New York, is known for his low-key, professorial style and organizational skills. While he was a favorite of Mr. Obama and other staff members as chief of staff, Mr. Lew made it known that he did not want to continue in that post for a second term.

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Google offers New York City neighborhood free WiFi

(Reuters) – Google Inc and a New York redevelopment organization are providing a Manhattan neighborhood with free public WiFi Internet access, making it the largest area of coverage in New York City.

The search giant and the non-profit Chelsea Improvement Co are making Internet access available outdoors in Chelsea, which is home to Google’s New York offices and several technology start-ups.

The neighborhood is also home to many students, as well as residents of one of the city’s public housing developments.

Google does not plan to extend the program, a company spokesman said on Tuesday.

The company also provides free Internet access to the city of Mountain View, California, where its main campus is located.

New York City Mayor Michael Bloomberg and U.S. Senator Charles Schumer helped unveil the initiative.

(Reporting by Jennifer Saba in New York; Editing by Dan Grebler)

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Face-off in Chinese City Over Censorship of Newspaper

Jonah M. Kessel for The New York Times

A free speech advocate outside of Southern Weekend newspaper in Guangzhou, China, on Tuesday.

GUANGZHOU, China — Protests over censorship at one of China’s most liberal newspapers descended into ideological confrontation on Tuesday, pitting advocates of free speech against supporters of Communist Party control who wielded red flags and portraits of Mao Zedong.

The face-off between liberals and leftists at the headquarters of a newspaper company in southern China came after disgruntled editors and reporters at Southern Weekend last week decried what they alleged was crude meddling by the head of party propaganda in Guangdong Province, which has long had a reputation as a bastion of a relatively free press.

The protesting journalists at Southern Weekend have called for the dismissal of Tuo Zhen, the top propaganda official in Guangdong Province. They blame Mr. Tuo, a former journalist, for making a drastic change in a New Year’s editorial that had originally called for greater respect for constitutional rights. The revised editorial instead praised Communist Party policies.

A former editor with the Southern Daily group of newspapers, which includes Southern Weekend, said negotiations continued on Tuesday between representatives of the disgruntled journalists and newspaper managers and provincial propaganda officials.

The former editor, who asked that his name not be used for fear it could jeopardize his new job, said the talks focused on the protesting journalists’ demands that the paper’s managers rescind a statement that denied that Mr. Tuo was responsible for the New Year editorial and for an inquiry into the incident.

“They want that statement to be removed, and they also want assurances about relaxing controls on journalists — not removing party oversight, but making it more reasonable, allowing reporters to challenge officials,” he said. “The other main demand is for an impartial explanation of what happened, an accounting so it won’t happen again.”

The former editor said a continued standoff into Wednesday could jeopardize the newspaper’s usual publication on Thursday. “In effect, it’s a strike,” he said. “It looks unclear whether it can come out on Thursday.”

Senior Chinese officials have so far not commented publicly on the censorship dispute at the newspaper, which has tested how far the recently appointed Communist Party leader, Xi Jinping, will extend his vows of economic reform into a degree of political relaxation. But self-proclaimed defenders of Communist orthodoxy who turned up at the newspaper headquarters said on Tuesday that they were there to make the party’s case.

“We support the Communist Party, shut down the traitor newspaper,” said one of the cardboard signs held up by one of 10 or so protesters who came to defend the government.

“Southern Weekend is having an American dream,” said another of the signs. “We don’t want the American dream, we want the Chinese dream.”

Some of the group held up portraits of Mao, the late revolutionary leader who remains a symbol of communist zeal, while others waved the red flags of China and of the Communist Party. Most of the party supporters refused to give their names. They said they came on their own initiative, and not at the behest of officials.

The dueling protests outside the newspaper’s headquarters in this provincial capital reflected the political passions and tensions churned up by the quarrel over censorship, which has erupted while Mr. Xi is trying to win public favor and consolidate his authority.

Hundreds of bystanders watched and took photos on mobile phones as the leftists shouted at the 20 or more protesters who had gathered to denounce censorship, and shoving matches broke out between the demonstrators.

At one point, leftists were showered with 50-cent renminbi currency notes. The “Fifty Cent Party” has become a popular term for disparaging pro-party leftists, who are alleged by critics to be willing to take 50 cents in payment for each pro-party message they send onto the Internet.

“It’s the only newspaper in China that’s willing to tell the truth,” said Liang Taiping, 28, a poet from the southern city of Changsha who said he took the train to Guangzhou to show his support for Southern Weekend, which is widely read nationwide.

“What’s the point of living while you can’t even speak freely?” he said.

About 70 police officers and security guards stood nearby. They did not try to break up the protests, but officers recorded them with video cameras and occasionally stepped in to stop shoving and fisticuffs. Later, the rival protesters broke into separate camps concentrated on different sides of the gate to the newspaper headquarters.

The protests at Southern Weekend broke out while Mr. Xi, the party’s general secretary appointed in November, has been sending mixed signals about his intentions. He has repeatedly said he supports faster and bolder reform, but on Saturday he gave a speech defending the party’s history and Mao’s standing in it.

The Central Propaganda Department, which administers the censorship apparatus, issued instructions telling news media that the dispute at Southern Weekend was “due to the meddling of hostile outside forces,” according to China Digital Times, a group based in Berkeley, Calif., that monitors media and censorship issues.

Both supporters and critics of Southern Weekend journalists have claimed that Mr. Xi would back their cause.

“I don’t believe that Xi is totally hypocritical when he talks about reform,” said Chen Min, a prominent former opinion writer for Southern Weekend who was forced out of the newspaper in 2011.

“The Southern Weekend journalists have said that they accept party control, but the question is what kind of control and how far should it go unchallenged,” Mr. Chen added.

Jonah Kessel reported from Guangzhou, China, and Chris Buckley from Hong Kong. Mia Li contributed reporting from Guangzhou, and Patrick Zuo from Beijing.

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Saban quickly turns to challenges of 2013 season

FORT LAUDERDALE, Fla. (AP) — It's becoming a familiar January scene for Nick Saban.

The Alabama coach plastered a smile on his face for a series of posed photos next to the various trophies awarded to college football's national champions and then proceeded to talk about the challenges facing his team.

Maybe Saban let the Gatorade dry from the celebratory drenching before thinking about the 2013 season. Maybe.

"The team next year is 0-0," Saban, who is on a 61-7 run over the past five seasons, said Tuesday morning. "Even though I really appreciate what this team accomplished and am very, very proud of what they accomplished, we need to prepare for the challenges of the new season very quickly with the team we have coming back. "

It didn't take Saban long to refocus after Monday night's 42-14 demolition of Notre Dame that secured a second straight BCS title, the Crimson Tide's third in four seasons and the seventh straight for Southeastern Conference teams.

Shortly after the game, he was already talking about getting back to the office by Wednesday morning.

Alabama players, meanwhile, finally were able to voice the "D-word." Center Barrett Jones said he had a Sports Illustrated cover from a couple of years ago after his last college game.

"It says, 'Dynasty. Can anybody stop Alabama?' I'll never forget looking at that thing and wondering if we really could be a dynasty," said Jones, who mainly put it on the wall because he's featured. "I think three out of four, I'm no dynasty expert, but that seems like a dynasty to me. I guess I can say that now that I'm gone. Don't tell coach I said that."

The 2013 team will almost certainly be regarded among the preseason favorites to get back to the summit, even though three Tide stars — tailback Eddie Lacy, cornerback Dee Milliner and right tackle D.J. Fluker — could decide to skip their senior seasons and turn pro.

Saban also emphatically tried to end speculation that he might return to the NFL, where he spent two years with the Miami Dolphins before returning to the SEC.

It was a question that really made him bristle during the 30-plus minute news conference.

"How many times do you think I've been asked to put it to rest?" Saban said. "And I've put it to rest, and you continue to ask it. So I'm going to say it today, that — you know, I think somewhere along the line you've got to choose. You learn a lot from the experiences of what you've done in the past. I came to the Miami Dolphins, what, eight years ago for the best owner, the best person that I've ever had the opportunity to work for. And in the two years that I was here, I had a very, very difficult time thinking that I could impact the organization in the way that I wanted to or the way that I was able to in college, and it was very difficult for me."

He said that experience taught him that the college ranks "is where I belong, and I'm really happy and at peace with all that."

As for the players, All-America linebacker C.J. Mosley has already said he'll return. So has quarterback AJ McCarron, who had his second straight star turn in a BCS title game.

"We certainly have to build the team around him," Saban said, adding that a late-game spat with Jones showed the quarterback's competitive fire. "I've talked a lot about it's difficult to play quarterback when you don't have good players around you. I think we should have, God willing and everybody staying healthy, a pretty good receiver corps. We'll have to do some rebuilding in the offensive line. Regardless of what Eddie decides to do, we'll probably still have some pretty decent runners. But I think AJ can be a really good player, maybe the best quarterback in the country next year."

The biggest question mark is replacing three, maybe four, starters on an offensive line that paved the way.

Amari Cooper, who broke several of Julio Jones' Alabama freshman receiving marks, and fellow freshman running back T.J. Yeldon give McCarron and the Tide a couple of potent weapons, even if Lacy doesn't return.

"I am going to try to win three or four," said Cooper, who had 105 yards and two touchdowns in the title game. "This season was good, but I expected it to be even more. There is so much more that I can do."

Saban emphasized the difficulty of repeating and said he showed the players a video of NBA Hall of Famer Michael Jordan saying that the first title isn't the hardest — it's the ones after that.

That's because, Saban said, "you have to have the will to fight against yourself."

Now, the 'Bama coach has four titles, including one during his stop at LSU. Saban doesn't wear the championship rings but uses them for a different purpose.

"I just put them on the coffee table for the recruits to look at," he said, cracking up the room.

Saban has already lined up another highly rated recruiting class and has the next wave of young talents waiting in the wings.

After all, he talked about the sign mentor Bill Belichick hung in the football building during their NFL days together: "Do your job."

Saban jokingly acknowledged that while he prepares for everything, the one thing he has never been able to anticipate is the Gatorade bath. He drew heat for a scowl after the first one, following the title game win over Texas when he got dinged in the head. Monday night's dousing went better.

"It's cold, it's sticky, but I appreciated not getting hit in the head with the bucket," Saban said. "That was an improvement."

No program has had this kind of championship run since Tom Osborne's Nebraska teams won it all in 1994, 1995 and 1997.

Saban remembers that second team well. The Cornuskers stomped Michigan State 50-10 in Saban's first game as head coach.

"I'm thinking, we're never going to win a game," Saban said. "We'll never win a game here at Michigan State. I must have taken a bad job, wrong job, no players, something. I remember Coach Osborne when we shook hands after the game, he put his arm around me and whispered in my ear, 'You're not really as bad as you think.'"

So take heart, college football.

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Gaps Seen in Therapy for Suicidal Teenagers

Most adolescents who plan or attempt suicide have already gotten at least some mental health treatment, raising questions about the effectiveness of current approaches to helping troubled teenagers, according to the largest in-depth analysis to date of suicidal behaviors in American teenagers.

The study, posted online Tuesday by the journal JAMA Psychiatry, found that 55 percent of suicidal teenagers had received some therapy before they thought about suicide, planned it or tried to kill themselves, contradicting the widely held belief that suicide is due in part to a lack of access to treatment.

The findings, based on interviews with a nationwide sample of more than 6,000 teenagers and at least one parent of each, linked suicidal behavior to complex combinations of mood disorders like depression and behavior problems that include attention-deficit and eating disorders, as well as alcohol and drug abuse.

The study found that about one in eight teenagers had persistent suicidal thoughts at some point, and about a third of them had made a suicide attempt, usually within a year of having the idea.

Previous studies have had similar findings, based on smaller, regional samples. But the new study is the first to suggest, in a large nationwide sample, that access to treatment does not make a big difference.

The study suggests that effective treatment for severely suicidal teenagers must address not just mood disorders, but also behavior problems that can lead to impulsive acts, experts said. According to the Centers for Disease Control and Prevention, 1,386 people between the ages of 13 and 18 committed suicide in 2010, the latest year for which numbers are available.

“I think one of the take-aways here is that treatment for depression may be necessary but not sufficient to prevent kids from attempting suicide,” said Dr. David Brent, a professor of psychiatry at the University of Pittsburgh, who was not involved in the study. “We simply do not have empirically validated treatments for recurrent suicidal behavior.”

The report said nothing about whether the therapies given were state of the art, or carefully done, said Matt Nock, a professor of psychology at Harvard and the lead author; and it is possible that some of the treatments prevented suicide attempts. “But it’s telling us we’ve got a long way to go to do this right,” Dr. Nock said. His co-authors included Ronald C. Kessler of Harvard, and researchers from Boston University and Children’s Hospital Boston.

Margaret McConnell, a consultant in Alexandria, Va., said that her daughter Alice, who killed herself in 2006, at the age of 17, was getting treatment at the time. “I think there might have been some carelessness in the way the treatment was done,” Ms. McConnell said, “and I was trusting a 17-year-old to manage her own medication; we found out after we lost her that she wasn’t taking it regularly.”

In the study, researchers surveyed 6,483 adolescents from the ages of 13 to 18 and found that 9 percent of male teenagers and 15 percent of female teenagers experienced some stretch of having persistent suicidal thoughts. Among girls, 5 percent made suicide plans and 6 percent made at least one attempt (some were unplanned).

Among boys, 3 percent made plans and 2 percent carried out attempts – which tended to be more lethal than girls’ attempts.

(Suicidal thinking or behavior was virtually unheard-of before age 10.)

Over all, about one-third of teenagers with persistent suicidal thoughts went on to make an attempt to take their own lives.

Almost all of the suicidal adolescents in the study qualified for some psychiatric diagnosis, whether depression, phobias, or generalized anxiety disorder. Those with an added behavior problem – attention-deficit disorder, substance abuse, explosive anger – were more likely to act on thoughts of self-harm, the study found.

Doctors have tested a range of therapies to prevent or reduce recurrent suicidal behaviors, with mixed success. Medications can ease depression, but in some cases can increase suicidal thinking. Talk therapy can contain some behavior problems, but not all.

One approach, called dialectical behavior therapy, has proved effective in reducing hospitalizations and attempts in people with so-called borderline personality disorder, who are highly prone to self-harm, among others.

But suicidal teenagers who have a mixture of mood and behavior issues are difficult to reach. In one 2011 study, researchers at George Mason University reduced suicide attempts, hospitalizations, drinking and drug use among suicidal adolescent substance abusers. The study found that a combination of intensive treatments – talk therapy for mood problems, family-based therapy for behavior issues and patient-led reduction in drug use – was more effective that regular therapies.

“But that’s just one study, and it’s small,” Dr. Brent said. “We can treat components of the overall problem, but that’s about all.”

Ms. McConnell said that her daughter’s depression seemed mild and that there was no warning that she would take her life. “I think therapy does help a lot of people, if it’s handled right,” she said.

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Wall Street Closes Lower as Earnings Reports Begin

Stocks trading on Wall Street ticked lower on Tuesday as an earnings season that is expected to show sluggish corporate growth got under way.

The Standard & Poor’s 500-stock index closed 0.3 percent lower, the Dow Jones industrial average lost 0.4 percent and the Nasdaq composite index fell 0.2 percent.

Over the next couple of weeks, reports on fourth-quarter profits are expected to come in above the previous quarter’s lackluster results, but analysts’ current estimates are down sharply from where they were in October. Quarterly earnings are expected to grow by 2.8 percent, according to Thomson Reuters data.

German data showed industrial orders fell more than forecast in November because of a sharp drop in demand from abroad, reinforcing concerns that Europe’s largest economy may have contracted in the fourth quarter of 2012.

“I’m surprised futures are holding up, given the relative disappointment that German data showed, but I think all eyes are on the beginning of earnings season,” said Kim Forrest, senior equity research analyst at Fort Pitt Capital Group in Pittsburgh.

European shares ended mixed after the German report, with the DAX index in Frankfurt down 0.5 percent and the CAC 40 in Paris up slightly.

Monsanto shares rose 2 percent after the world’s largest seed company raised its earnings outlook for fiscal 2013 and posted strong first-quarter results.

Shares of the restaurant-chain operator Yum Brands fell 4.2 percent. On Monday, the company, which owns KFC, warned that sales in China, its largest market, shrank more than expected in the fourth quarter.

Vodafone shares rose 2 percent in London after its American partner in the joint venture Verizon Wireless said it would be “feasible” to buy out the British group.

Sears Holdings shares were 6.4 percent lower a day after the company said its chief executive would step down for family health reasons.

GameStop shares fell 6.3 percent after it reported sales for the holiday season and cut its guidance.

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Mark Zuckerberg faces fine in Germany over Facebook privacy violations

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Klemens von Klemperer Dies at 96; Wrote of Nazi Era

Klemens von Klemperer, a refugee from Nazi Germany who wrote what is widely considered the seminal history of the movement among the country’s conservative elite to overthrow Hitler, died on Dec. 23 at his home in Easthampton, Mass. He was 96.

His death was confirmed by his son, James.

Dr. von Klemperer, an emeritus professor of history at Smith College, was one of a generation of refugee historians who helped lay the groundwork for modern German and European studies in the United States, a group that also included Hajo Holborn, Fritz Stern and Peter Gay.

A privileged child who came from a family of German bankers and industrialists, he had taken a leading role in demonstrations against Hitler as a student in Vienna before fleeing to the United States in 1938.

Dr. von Klemperer, the author of seven books, was best known for his 1992 work, “German Resistance Against Hitler: The Search for Allies Abroad, 1938-1945.”

On July 20, 1944, in the signature moment for the movement, Count Claus von Stauffenberg, a German Army colonel, placed a briefcase containing a bomb under the map table at Wolfsschanze, Hitler’s headquarters in a bunker in East Prussia. Hitler survived the ensuing blast, proclaiming divine providence, and set off a wave of executions of conspirators.

Dr. von Klemperer’s book explored the broader aims of the resistance movement and how its leaders — among them the aristocrat Helmuth James von Moltke and the theologian Dietrich Bonhoeffer, as well as diplomats and high-ranking military men — had made many contacts seeking support from the Western Allies.

“He really charted the foreign contacts of that group; that’s the importance of von Klemperer’s work,” Catherine Epstein, chairwoman of the history department at Amherst College and an expert on German history, said in an interview. “These were very nationalistic resisters. They wanted to have an independent Germany, did not want to be occupied by the Allies.”

Their outreach was thwarted by the Allies’ goal of unconditional German surrender and by a lack of trust in the resistance movement. Yet, for Dr. von Klemperer, their efforts achieved a higher goal.

“He attempted to show that there were indeed good Germans, and that they were deeply, morally offended by the Nazis,” said Allan Mitchell, who profiled Dr. von Klemperer in his 2011 book “Fleeing Nazi Germany: Five Historians Migrate to America.” “That’s what was most important to him.”

In “German Resistance Against Hitler,” Dr. von Klemperer wrote, “The determination of the German Resistance to reach the ‘greater world’ stands as an example for the many dissidents and freedom movements who in our day, still plagued by oppression, are appealing to the conscience of the world.”

Klemens Wilhelm von Klemperer was born in Berlin on Nov. 2, 1916, into what had been a Jewish family until his grandfather, Gustav, the director of one of Germany’s largest banks, converted to Protestantism.

Klemens’s father, Herbert, was the president of a company that manufactured locomotives, submarines and torpedoes for the German military.

That status and the family’s conversion mattered less and less after anti-Jewish laws were passed in 1933. In 1935, young Klemens joined his mother’s family in Vienna.

He studied history at the University of Vienna and, after Hitler’s annexation of Austria in March 1938, took part in student street protests. But by November, with his family’s property seized, he had fled to the United States. Eventually, members of his family were killed at Auschwitz.

He enrolled at Harvard under a program for refugee scholars, but his studies were interrupted by his service as an intelligence officer in the United States Army. After returning to Harvard, he received his doctorate in history in 1949 and soon joined the faculty at Smith, where he taught for 37 years.

Among Dr. von Klemperer’s other books are “A Noble Combat: The Letters of Shiela Grant Duff and Adam von Trott zu Solz, 1932-1938” (1988), about the romantic relationship of a British woman and a German diplomat as they struggled with their concerns about the Nazi regime, and “Ignaz Seipel: Christian Statesman in a Time of Crisis” (1972), a biography of an Austrian priest who became chancellor in the 1920s.

Besides his son, Dr. von Klemperer is survived by his wife of 59 years, the former Elizabeth Gallaher; a daughter, Catharine Utzschneider; and four grandchildren.

Three years ago, Dr. von Klemperer’s memoir, “Voyage Through the 20th Century,” was published.

“I was not an extraordinary person, but I did live in extraordinary times,” he wrote, “and my small mission was somehow to make sense of it all.”

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Redskins' RG3 to have more tests on ACL

ASHBURN, Va. (AP) — Robert Griffin III will get more tests on his injured right knee after an MRI proved inconclusive because of a previous ACL tear.

Washington Redskins coach Mike Shanahan said Monday that the rookie quarterback will travel Tuesday to see orthopedist James Andrews for more examinations.

Griffin tore his ACL while playing at Baylor in 2009, and Shanahan said sometimes an old injury can cloud the results of an MRI.

If Griffin has torn the ACL again, he would likely require a rehabilitation period of nine to 12 months, putting his status for next season in jeopardy.

Griffin reinjured his knee twice in Sunday's playoff loss to Seattle.

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